Duke Nukem 3D
First person shooter based on the 2.5D Build engine, developed by 3D Realms and released in 1996. For gameplay on modern computers, using a source port is recommended. The DOS version is known to have problems with Creative Labs cards.
When using an AWE32 or AWE64 card in Win9x and selecting the appropriate mode in the game, the music will come out garbled. This is possibly related to the particular implementation of the EMU8K synth on those cards and can be fixed by running a MIDI file before starting the game. This problem is not present in MS-DOS.
Furthermore, on all Creative cards, when using an external MIDI synth and appying sound FX frequencies over 11250kHz, sound playback will stutter, with potentially missing parts of the MIDI music. Most cards from other brands should not have this problem.
When using General Midi as playback device for music Duke Nukem 3D sends no GM reset on startup. This way the musical score sounds different depending on the synthesizers mode e.g. GM or GS prior running Duke Nukem 3D.